Chemoprevention for Lynch patients

Chemoprevention of endometrial cancer in Lynch syndrome: a step forward.

Lynch syndrome is one of the most common hereditary cancer syndromes. Although Lynch syndrome is associated with increased risk for developing colorectal, endometrial, and other cancers specialized screening, risk-reducing surgery, and chemoprevention offer promise for reducing morbidity and mortality. Frequent colonoscopic surveillance has proven effective for early detection and prevention of...

Pancreatic Cancer in Lynch Syndrome Patients

Although colorectal cancer (CRC) is the most common cancer type in Lynch syndrome (LS) families, patients have also increased lifetime risk of other types of tumors. The accumulated risk of pancreatic cancer (PC) in LS patients is around 3.7% and developed tumors often present a characteristically medullary appearance with prominent lymphocytic infiltration. LS patients are considered in high r...

Chemoprevention for colorectal cancer in ulcerative colitis patients

(mesalazine), used for both induction and maintenance of remission therapy, in epidemiological retrospective studies. There is also supportive experimental evidence that 5-ASA agents increase apoptosis, decrease proliferation and inhibit the formation of aberrant crypt foci, as well as reducing the spontaneous mutation rate at a (CA) 13 microsatellite, a mutation linked with chronic inflammatio...

G Lynch

meant by "more effective." This unqualified assertion is likely to confuse the many people who already use or recommend All-Bran as an "effective" means of avoiding constipation whatever its soluble:insoluble fibre ratio or influence on plasma lipids, mineral absorption, faecal bulking, bowel transit time, etc. Furthermore, it is difficult to see why "wholemeal bread and crispbreads" are the on...

Sean Lynch ,